Endocrine Abstracts

Introductıon: Rathke’s cleft cysts (RCCs) are benign lesions originating from the epithelial remnants of Rathke’s pouch with a peak incidence at 30–50 years of age. It is detected at a rate of 13–33% in several autopsy series. RCC is usually asymptomatic and diagnosed incidentally. In symptomatic cases, common symptoms are headache, visual disturbance, and symptoms related to hypopituitarism.Case: A 28-year-old male patient prese...

Context: Polycystic ovary syndrome (PCOS) is associated with an increased cardiometabolic risk that might not necessarily translate into adverse cardiovascular outcome later in life. Recently, alterations in gut microbial composition have been reported in the syndrome. Microbiota-dependent metabolite trimethylamine N-oxide (TMAO) and its precursors are closely linked with development of atherosclerotic cardiovascular disease, independently of traditional risk factors.<p cl...

Introduction: Acromegaly is a chronic disorder characterized by chronic growth hormone (GH) excess. In most of cases, GH hypersecretion is derived from somatotroph cell tumors. Survivin is a member of apoptosis protein family, which was recently showed to be expressed in different benign and malignant human tumors. A number of studies showed overexpression of survivin in pituitary adenomas. This study is intended to determine circulating levels of survivin in patients with acr...

Introduction: Polycystic ovary syndrome (PCOS) is a common endocrinopathy associated with increased cardiovascular risk in reproductive aged women. Circulating osteoprotegerin (OPG) and soluble receptor activator of nuclear factor κB ligand (sRANKL) are associated with subclinical atherosclerosis. Our aim is to evalutate serum OPG and sRANKL levels and their relations with cardiovascular and metabolic markers in paients with obese and non-obese PCOS.<p class="abstext"...

Introduction: We aimed to determine changes in geriatric assessment of cases with acromegaly.Methods: 26 elderly cases with acromegaly (controlled/uncontrolled: 15/11, F/M: 17/9) were included. 20 age, gender and BMI matched cases without acromegaly composed control group (CG) (F/M: 10/10). Presence of concomitant diseases and educational level were not different between the groups. Cognitive functions were evaluated with Mini Mental State Exam (MMSE), a...

Background: Currently, multiple treatment options are available for the treatment of acromegaly. However, cure is obtained only in 50% of patients with macroadenomas after surgery. Persistent tumor enlargement occur in 2.2% of the patients treated with somatostatin analogs and in 1.6–2.9% of the patients treated with pegvisomant. The nuclear antigen Ki-67 is related to growth potential and is also a major prognostic indicator for pituitary adenomas. Studies demonstrated t...

Although adrenal gland involvement may be seen in patients with diffuse (non-Hodgkin) lymphoma, primary adrenal lymphoma is quite rare and adrenal insufficiency accompanies the clinical picture in 2/3 of cases.Case: A 70-year-old male patient presenting with anorexia and weight loss was referred to our clinic for bilateral adrenal masses, which were detected by abdominal computerized tomography (CT) as 5.2×5.2×2.7 cm in the right adrenal and 11...

Introduction: It has been shown with many studies that sulphonylureas may have a negative effect on parameters of insulin resistance while improving glucose regulation. However not all of the sulphonylureas have the same effect. This analysis assessed the different effects of sulphonylureas on some metabolic parameters of insulin resistance.Method: Newly diagnosed 25 T2DM individuals who were naive of oral antidiabetic therapy were recruited and randomiz...

Aim: To determine how serum procalcitonin (PCT) levels are affected in diabetic and diabetic nephropathic patients, it is important to determine whether PCT is indicative of an inflammation in these patients.Materials and methods: The study included 175 patients (75 diabetic nephropathy (group 1), 75 diabetic (group 2) and 25 non-diabetic nephropathy (group 3)) and 75 healthy volunteers. Serum and urine creatinine, serum high sensitive C- reactive protei...

Macro TSH is a large molecular-sized thyroid-stimulating hormone (TSH) that is including TSH and anti-TSH antibody. Patients with macro TSH have elevated serum TSH and normal free thyroxine levels similar to subclinical hypothyroidism. A 18-year old female patient was referred from gynecology and obstetrics to endocrinology clinic for evaluating of elevated TSH with normal free thyroxine levels. Laboratory and clinical investigations revealed that only discordant TSH levels (n...